变应性鼻炎大鼠模型的文献研究

摘要

Through summarization on published literatures on allergic rat model in recent 20 years, domestic current research status and trend were analyzed. Some insights were provided on how to build a standard process for modeling and post-modeling evaluation. “Allergic rhinitis,” “rat model of allergic rhinitis”, or “animal experiment” was used as search terms. Related published articles were searched in the CNKI database from August, 1993 to October, 2013. Documents and data, including modeling method, drug dose, modeling cycle, model assessment described in the articles were extracted, summarized and quantitative analyzed. The results showed that 208 valid articles were included in this study. SD rat was used as animal model. Ovalbumin plus aluminum hydroxide were used as adjuvant sensitizing agents. Intraperitoneal injection plus nasal stimulation were the most commonly used modeling method. Behavioral evaluation scale score was used as the main evaluation index. It was concluded that currently there were many methods for allergic rhinitis animal modeling domestically. The post-modeling evaluation was relatively single. It was urgent and necessary to establish the standard process for modeling and post-modeling evaluation for allergic rhinitis animal model.%目的：通过对近20年发表变应性大鼠造模的文献进行总结，对国内目前研究现状及动态进行分析，并为如何建立标准化的造模流程及造模后评价提供部分见解。方法：以“变应性鼻炎”和“变应性鼻炎大鼠模型”或“动物实验”为检索词，对中国知网（CNKI）数据库中于1993年8月-2013年10月发表的相关文献进行检索，对文献中描述的造模方式、药物剂量、造模周期、模型评价等进行资料、数据提取后进行归纳及量化分析。结果：本次研究共纳入208篇有效文献，以SD大鼠为造模动物，卵清蛋白＋氢氧化铝为致敏剂和佐剂，以腹腔注射＋鼻腔激发造模是最常用的造模方式，动物行为学观察量化评分为主要评价指标。结论：目前国内在变应性鼻炎动物造模方面形式多样，造模后评价方式较为单一，建立标准化的变应性鼻炎造模流程及造模后评价亟待所需。