Anticonvulsant activity of allopregnanolone against pentylenetetrazol- induced seizures in rodents

摘要

Objective To examine the protective effects of allopregnanolone against pentylenetetrazol－ induced seizures. Methods The protective effects of allopregnanolone against pentylenetetrazol－ induced seizures were studied in C57 mice and SD rats 15 minutes after vehicle or drug intraperitoneal (ip) administration. Results The pretreatment with the allopregnanolone produced a dose－ dependent protective effect against pentylenetetrazol－ induced seizures. The potencies (ED50 values) were 4.7 mg/kg and 9.8 mg/kg for mice and rats, respectively. Conclusion Allopregnanolone has anticonvulsant activity against pentylenetetrazol－ induced seizures in rodents.