细菌DNA损伤诱导反应(SOS 反应)在控制细菌耐药性中的作用

摘要

细菌耐药性是当前最紧迫的公众健康问题之一,尤其在目前新型抗菌药物研发落后于耐药菌进化速度的情况下,细菌耐药性的发生、传播以及消除的机制,已经成为人们关注的热点。近来研究发现,细菌DNA损伤诱导反应(SOS反应)在细菌进化耐药性的过程中扮演着重要角色。在这里,本文对SOS反应与细菌耐药性的关系、研究进展以及当前存在问题作一阐述。Bacterial drug resistance is one of the world’s most pressing public health threats. Especially in today, new antimicrobial drugs are no longer being developed at a rate that can keep pace with microbial evolution. The mechanism for the emergence, spread and reversion of bacterial resistance has become a research hotspot. Recently, it has been proved that bacterial DNA damage response (also named SOS response) acts an important role in the evolution of drug resistance. Here, we reviewed the relation between SOS response and bacterial drug resistance.