Guangdong Traditional Medical and Sports Injury Rehabilitation Research Institute Guangdong Second Provincial General Hospital Guangzhou 510317 China;
Center for Drug and Clinical Research Southern Hospital Southern Medical University Guangzhou 510515 China;
Department of Traditional Chinese Medicine the First Affiliated Hospital of Jinan University Guangzhou 510632 China;
Department of Urology Shanghai Zhongye Hospital Shanghai 201900 China;
Manshenkangning; Renal interstitial fibrosis; Oxidative stress; Inflammatory reaction; Silent information regulator 1(SIRT1); Cyclooxygenase-2(COX-2);