Expression and clinical significance of serum galactose lectin-2 and transforming growth factor-β2 in patients with atrial fibrillation

摘要

Objective:To investigate the expression of serum transforming growth factorβ2(TGF-β2)and galectin-2(Galectin-2)in patients with atrial fibrillation and its clinical significance.Methods:A total of 150 inpatients in the Department of Cardiology of the First Affiliated Hospital of Bengbu Medical College from January 2019 to June 2019 were selected,including 84 patients in the paroxysmal atrial fibrillation group,66 patients in the persistent atrial fibrillation group,and 120 patients with sinus rhythm excluding atrial fibrillation who were hospitalized during the same period were selected as the control group.Blood routine,biochemical routine and cardiac ultrasonic morphological examination were improved after admission.In addition,the serum levels of TGF-β2 and Galectin-2 in each group were detected by Elisa and Western Blot,and the differences and clinical significance of TGF-β2 and Galectin-2 in different groups were statistically analyzed.The correlation between TGF-β2,Galectin-2 and left atrial end-diastolic diameter(LAD)was further determined by Pearson correlation analysis.By means of binary logistics regression analysis,the factors affecting atrial fibrillation were obtained.Results:Compared with the control group,age and LAD in atrial fibrillation group were significantly increased(P<0.05).The serum concentrations of TGF-β2 and galectin-2 in persistent af group were significantly increased compared with those in paroxysmal af group and control group(P<0.05),while those in control group were significantly decreased compared with paroxysmal AF group(P<0.05).Pearson correlation analysis showed that TGF-β2 and Galectin-2 concentrations were significantly positively correlated with LAD size in the experimental group(P<0.05).Binary logistic regression analysis showed that TGF-β2,galectin-2 and LAD were risk factors for atrial fibrillation(P<0.05).Conclusion:TGF-β2 and Galectin-2 are closely related to the occurrence and development of atrial fibrillation.Both TGF-β2 and Galectin-2 were positively correlated with LAD.The three have a synergistic effect on the occurrence and progression of atrial inflammatory fibrosis in patients with ATRIAL fibrillation,jointly promoting mechanical and electrical remodeling of atrial,and can be used as risk factors to evaluate the occurrence and progression of atrial fibrillation.