Review the oncogenic mechanism of autophagy protein p62 and the relationship between p62 and gynecological malignant cancer

摘要

There are many fuctions with the representative autophagy associated protein p62,such as cell signal transduction,cell proliferation,apoptosis,inflammation,tumorigenesis and oxidative stress.p62 over express will lead to autophagy disorder by controlling keap1-Nrf2mTORC1,NF-κB signaling pathways,thus promoting the development of the tumor.The overexpression of p62 in tissues can lead to the occurrence of the gynecological malignant tumors,such as ceicival cancer,ovarian carcinoma and Endometrial carcinoma.And the level of p62 is correlated with the tumor progression,the tumor grade and the survival rates of patients.p62 and its upstream and downstream molecules are expected to be the markers and therapeutic targets for predicting the clinical outcome of the gynecological malignant cancer patients.