Meta-analysis of the efficacy and safety of Lianhua Qingwen combined with western medicine in the treatment of common patients with new coronary pneumonia

摘要

Objective:To evaluate the clinical efficacy of Lianhua Qingwen combined with Western medicine in the treatment of common patients with new coronary pneumonia by Meta analysis system.Methods:Computer retrieval of Chinese Journal Full-text Database,Weipu Chinese Scientific and Technical Periodical Full-text Database,Wanfang Data Knowledge Service Platform,Chinese Biomedical Literature Database,PubMed Database and manual retrieval of relevant literature.The search period is from database establishment to April 2020 Two researchers independently searched,screened the literature,and performed data extraction and quality evaluation on the included literature according to the Cochrane systematic review methodology.RevMan5.3 software was used for Meta analysis.Results:A total of 5 RCT literatures were included in this study,and the total effect value was combined using a fixed-effect model.As a result,3 literatures were used for clinical efficacy statistics RR=2.59,95%CI(1.68,3.98),Z=4.32,P<0.05,statistically significant;there are 3 literatures on the disappearance rate of the main symptoms,including the disappearance of fever,cough and fatigue,subgroup study,no heterogeneity between the three groups(I2=0%,P=0.88),combined with RR=3.27,95%CI(2.18,4.91),Z=5.75,P<0.05,with statistical significance;there are 3 articles with statistics on the disappearance rate of comorbidities RR=13.68,95%CI(2.80,66.79),Z=3.23,P<0.05,which is statistically significant;there are 2 literatures that count the fever remission time MD=-1.07,95%CI(-1.77,-0.37),Z=2.99,P<0.05,Statistically significant;2 literatures reported aggravating conditions in the treatment group,RR=0.33,95%CI(0.13,0.81),Z=2.41,P<0.05,statistically significance.Conclusion:Lianhua Qingwen combined with Western medicine is effective in the treatment of common patients with new coronary pneumonia,and there are few adverse reactions.However,due to the limitations of the included literature,the Meta analysis results also have corresponding limitations,so more high-quality RCT is needed to further In-depth study.