Research progress of quinolinic acid in neuropsychiatric diseases

摘要

Quinolinic acid is a neurotoxic substance produced by tryptophan through the kynurenine metabolism pathway.Quinolinic acid is involved in the pathological processes of Alzheimer''s disease,Parkinson''s disease,Huntington''s disease,amyotrophic lateral sclerosis,encephalitis,depression,and schizophrenia.The above process is realized through pathophysiological processes such as excitatory neurotoxicity,metabolic damage,free radical generation and oxidative stress,participation in inflammatory response,induction of neuron and astrocytic apoptosis.This article will explain the metabolic regulation,biological characteristics,and neurotoxicity of quinolinic acid.The research progress of quinolinic acid in Alzheimer''s disease,Parkinson''s disease,Huntington''s disease,depression and subacute sclerosing panencephalitis is also described.