Experimental study on the protective effect of Chinese medicine Ruanganyin on the liver of HBV transgenic mice

摘要

Objective: To study the protective effect of ruanganyin on the liver of HBV transgenic mice. Methods: 50 half HBV transgenic mice, male and female, were randomly divided into treatment group (high, medium and low dose Ruanganyin), model group, positive control group (entecavir dispersible tablet) and 10 non HBV transgenic mice as blank control. The mice were killed after 4 weeks of drug intervention.The serum levels of ALT, AST, TBIL, LN, HA, IV-C and PCIII were observed. Results: (1) compared with the blank control group, the ALT,AST and TBIL levels in the model group were significantly higher than those in the blank control group (P 0.05). (2) Compared with the blank control group, the level of LN, HA, IV-C and PCIII in the model group was significantly higher than that in the blank control group (P 0.05). Conclusion: Chinese medicine Ruanganyin has the effects of protecting liver, reducing enzyme and anti fibrosis, but its mechanism of anti fibrosis needs further study.