Effect of preoperative paclitaxel + cisplatin neoadjuvant chemotherapy on the proliferation and invasion of cancer cells in esophageal cancer

摘要

cqvip:Objective: To investigate the effect of preoperative paclitaxel + cisplatin neoadjuvant chemotherapy on the proliferation and invasion of cancer cells in esophageal cancer. Methods: A total of 106 patients with esophageal cancer who underwent radical operation for esophageal cancer in our hospital between September 2014 and March 2017 were divided into the neoadjuvant chemotherapy group (n=54, receiving preoperative paclitaxel + cisplatin neoadjuvant chemotherapy) and the normal group (n=52, receiving no preoperative neoadjuvant chemotherapy) according the therapeutic regimen. The differences in the expression of proliferation genes and invasion genes in the postoperative lesion tissue specimens were compared between the two groups. Results: The proliferation genes MACC1, Nucleostemin, TRAF4 and USP39 mRNA expression in lesion tissue of neoadjuvant chemotherapy group were lower than those in lesion tissue of normal group whereas DEC1, PTPN14, KLF4 and LATS1 mRNA expression were higher than those in lesion tissue of normal group;invasion genes EphA2, MACC1, MMP-9, PFN2, Snail and SphK1 mRNA expression in lesion tissue of neoadjuvant chemotherapy group were lower than those in lesion tissue of normal group whereas PTEN and RACK1 mRNA expression were higher than those in lesion tissue of normal group. Conclusion: The paclitaxel + cisplatin neoadjuvant chemotherapy before esophageal cancer surgery can effectively inhibit the proliferation and invasion activity of esophageal cancer cells.