Correlation of the pathological features of benign and malignant thyroid nodules with ultrasonic elastography parameters

摘要

cqvip:Objective:To investigate the correlation of the pathological features of benign and malignant thyroid nodules with ultrasonic elastography parameters.Methods:A total of 176 patients with thyroid tumor who underwent thyroid tumor resection in this hospital between September 2016 and February 2018 were chosen as the research subjects, the 119 patients with thyroid cancer were selected as thyroid cancer group and the 57 patients with thyroid adenoma were selected as thyroid adenoma group. The thyroid cancer-related proliferation gene and thyroid cancer-related invasion gene expression as well as ultrasonic strain ratio in tumor tissues were compared between the two groups, and Pearson test was used to evaluate the correlation between above malignant molecule expression and ultrasonic strain ratio.Results: Thyroid cancer-related proliferation genes FOXA1, YAP and TPX2 mRNA expression in lesion tissues of thyroid cancer group were higher than those of thyroid adenoma group whereas EGCG and PDCD4 mRNA expression were lower than those of thyroid adenoma group;thyroid cancer-related invasion genes BRD4, Twist1, FoxM1 and SIRT1 expression were higher than those of thyroid adenoma group whereas Wortmannin and HIC1 mRNA expression were lower than those of thyroid adenoma group;ultrasonic strain ratio was higher than that of thyroid adenoma group. The Pearson test showed that the proliferation gene and invasion gene expression in thyroid cancer tissues were directly correlated with the ultrasonic strain ratio level.Conclusion: Thyroid cancer-related proliferation gene and invasion gene expression are directly correlated with ultrasonic strain ratio level, and ultrasonic elastography can be the reliable means to judge benign and malignant thyroid nodules.