Clinical effect of interferon combined with inhalant therapy for acute attack of bronchial asthma

摘要

Objective:To investigate the clinical effect of interferon combined with inhalant therapy for acute attack of bronchial asthma.Methods: A total of 56 patients with acute attack of bronchial asthma who were treated in our hospital between January 2015 and January 2018 were selected as the research subjects, and the therapies were reviewed and used to divide the patients into the control group (n=30) who received conventional inhalant therapy and the interferon group (n=26) who received interferon combined with inhalant therapy. Control group received salbutamol aerosol inhalation, and interferon group received interferon combined with salbutamol aerosol inhalation. The differences in serum levels of inflammatory factors, airway remodeling indexes and immunoglobulins were compared between the two groups immediately after admission and after 48 h of treatment.Results:Immediately after admission, the differences in serum levels of inflammatory factors, airway remodeling indexes and immunoglobulins were not statistically significant between the two groups of patients. After 48 h of treatment, serum inflammatory factors IL-8, IL-17, IL-18, IL-25, IL-27 and IL-33 levels of interferon group were lower than those of control group;airway remodeling indexes VEGF, MMP-9 and TIMP1 levels were lower than those of control group;immunoglobulins IgA, IgG and IgM levels were higher than those of control group whereas IgE level was lower than that of control group.Conclusion:interferon combined with inhalant therapy can effectively reduce systemic inflammatory response, inhibit airway remodeling and optimize humoral immune function in patients with acute attack of bronchial asthma.