cqvip:Objective: To study the detection and study of serum biochemical indexes in elderly patients with type 2 diabetes mellitus with osteoporotic fracture, and to provide reference for clinical diagnosis and treatment. Methods: A retrospective analysis of our hospital from December 2014 to December 2017 were elderly type 2 diabetic patients with osteoporotic fractures in 154 cases as the observation object, the other during the same period were selected in elderly type 2 diabetic osteoporosis fracture group of 166 cases of elderly type 2 diabetes mellitus group of 192 cases, 120 cases of healthy persons. The changes of serum biochemical indexes in the four groups were compared, and the changes of serum biochemical indexes in different age and gender patients were compared according to sex and age. Results: Compared four groups of patients with type 2 diabetes, serum CTX, P1NP, ALP and OC group is lower than fracture fracture group, osteoporosis group, control group, serum CTX, P1NP, ALP and OC were lower than the other three groups, the differences were statistically significant, but the fracture group and fracture osteoporosis no comparison between the two groups the difference. In terms of gender, the serum CTX, P1NP, ALP and OC levels in fracture group, osteoporotic fracture group and type 2 diabetes group were lower than those in female patients, and there was no significant difference between the above indexes in the control group and those in the control group. In terms of age, fracture group, osteoporosis group, bone fractures in type 2 diabetic group and control group four group age <60 patients serum CTX, P1NP, ALP and OC were lower than those of 60 years of age or older group. Conclusion: The serum markers of bone CTX, P1NP, ALP and OC in elderly patients with type 2 diabetes mellitus osteoporotic fracture increased significantly, and increased with the severity of the disease, which is worthy of clinical reference.
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