Effects of adjuvant ginkgolide injection therapy in perioperative period of hypertensive cerebral hemorrhage on neural functional recovery

摘要

cqvip:Objective: To study the effects of adjuvant ginkgolide injection therapy in perioperative period of hypertensive cerebral hemorrhage on neural functional recovery. Methods: Patients with hypertensive cerebral hemorrhage who underwent evacuation of hematoma in Traditional Chinese Medicine Hospital of Shunyi District Beijing between June 2015 and October 2017 were selected and divided into ginkgolide group and normal control group according to the perioperative application of ginkgolide injection or not in the history data. The levels of nerve injury markers and inflammatory stress mediators in serum as well as the expression of inflammatory stress signal molecules in peripheral blood were measured before treatment and 7 d after treatment. Results: Compared with same group before treatment, serum GNS and BDNF levels as well as peripheral blood Wnt1, GSK-3β and β-catenin expression of both groups of patients were significantly higher whereas serum Tau, NSE, OPN, MIF, HMGB1, TNF-α and MDA levels as well as peripheral blood eNOS and p38MAPK expression were significantly lower 7 d after treatment, and serum GNS and BDNF levels as well as peripheral blood Wnt1, GSK-3β and β-catenin expression of ginkgolide group 7 d after treatment were higher than those of normal control group whereas serum Tau, NSE, OPN, MIF, HMGB1, TNF-α and MDA levels as well as peripheral blood eNOS and p38MAPK expression were lower than those of normal control group. Conclusion: Adjuvant ginkgolide injection therapy in perioperative period of hypertensive cerebral hemorrhage can reduce the degree of nerve injury and inhibit the degree of inflammatory stress.