Effects of clopidogrel on coagulation function, antioxidant and related cytokines in patients with coronary heart disease

摘要

cqvip:Objective: To investigate the effects of clopidogrel on coagulation function, antioxidant and related cytokines in patients with coronary heart disease. Methods: A total of 160 patients with coronary heart disease were collected and randomly divided into control group and observation group, 80 cases in each group. The patients in the control group were treated with rosuvastatin calcium tablets and aspirin, and patients in the observation group were treated with clopidogrel on the basis of the control group. The serum levels of MCP-1, sE-selectin, PT, APTT, TT, FIB, TAC, SOD, sCD40L, VASP and tPAI-1 were compared before and after treatment in two groups. Results: After treatment, the levels of MCP-1, sE-selectin, FIB, tPAI-1 and sCD40L in the serum of the patients in the two groups were significantly lower than those before the treatment, and the levels of MCP-1, sE-selectin, FIB, tPAI-1 and sCD40L of the patients in the observation group were significantly lower than those in the control group, all differences were significant. After treatment, the levels of serum T-AOC, SOD and VASP of the patients in the two groups were significantly higher than those before the treatment, and the levels of T-AOC, SOD and VASP of the patients in the observation group were significantly higher than those in the control group, all differences were significant. Conclusion: Clopidogrel has a good effect on patients with coronary heart disease, and it can improve coagulation function and antioxidant capacity. The effect is remarkable.