Correlation of the changes of blood brain barrier permeability with the activation of apoptosis, inflammatory response and stress response in rats with cerebral hemorrhage

摘要

cqvip:Objective:To study the correlation of the changes of blood brain barrier permeability with the activation of apoptosis, inflammatory response and stress response in rats with cerebral hemorrhage.Methods: SD rats were chosen as experimental animals and divided into the cerebral hemorrhage group and the control group. 24 h after molding, formamide soaking method was referred to determine the levels of blood brain barrier permeability parameters as well as the contents of apoptosis molecules, inflammatory response molecules and oxidative stress molecules in brain tissues around the hematoma.Results: Blood brain barrier permeability parameter EB level in brain tissues around hematoma of cerebral hemorrhage group was significantly higher than that of control group, and DKK1, PAR-1, Bax, Cyt-C, NF-κB, ICAM1, VCAM1, TNF-α, MMP9, NOX4 and MDA contents were higher than those of control group, andβ-catenin, Bcl-2, Mn-SOD, GSH and T-AOC contents were lower than those of control group;Pearson correlation analysis showed that EB level in brain tissues around hematoma of cerebral hemorrhage group was positively correlated with DKK1, PAR-1, Bax, Cyt-C, NF-κB, ICAM1, VCAM1, TNF-α, MMP9, NOX4 and MDA contents, and negatively correlated withβ-catenin, Bcl-2, Mn-SOD, GSH and T-AOC contents. Conclusion:The increase of blood brain barrier permeability in rats with cerebral hemorrhage is related to the excessive activation of apoptosis, inflammatory response and stress response.