Serum Galectin-3 and sST2 contents in patients with chronic heart failure and their correlation with disease severity

摘要

cqvip:Objective:To study the serum Galectin-3 and sST2 contents in patients with chronic heart failure and their correlation with disease severity.Methods: Patients who were diagnosed with chronic heart failure in Guangrao County People's Hospital between March 2015 and October 2017 were selected as the heart failure group of the research, and the healthy subjects who received physical examination in Guangrao County People's Hospital during the same period were selected as the control group of the research. Serum was collected to detect the levels of Galectin-3, sST2 and ventricular remodeling indexes, and the echocardiography was performed to measure LVEDD, LVEF and LVMI.Results:Serum Galectin-3 and sST2 contents of heart failure group were significantly higher than those of control group, serum Galectin-3 and sST2 contents of patients with cardiac function grade Ⅲ and Ⅳ were significantly higher than those of patients with cardiac function grade Ⅱ, and serum Galectin-3 and sST2 contents of patients with cardiac function grade IV were significantly higher those of patients with cardiac function grade Ⅲ;LVEDD and LVMI levels as well as serum FGF23, MMP9, PICP and PIIICP contents of heart failure group were significantly higher than those of control group and positively correlated with serum Galectin-3 and sST2 contents whereas LVEF level as well as serum TIMP1 and TIMP4 contents was significantly lower than those of control group and negatively correlated with serum Galectin-3 and sST2 contents.Conclusion:The abnormal increase of serum Galectin-3 and sST2 in patients with chronic heart failure is valuable for evaluating the cardiac hypofunction and ventricular remodeling.