Effect of bifidobacterium enteral nutrition on intestinal flora and systemic inflammatory stress in patients with severe stroke

摘要

cqvip:Objective:To study the effect of bifidobacterium enteral nutrition on intestinal flora and systemic inflammatory stress in patients with severe stroke.Methods: Patients with severe stroke who were treated in our hospital between March 2015 and July 2017 were selected and randomly divided into the observation group who accepted bifidobacterium enteral nutrition and the control group who accepted conventional enteral nutrition, and the contents of intestinal flora in feces as well as the contents of intestinal mucosal barrier markers, inflammatory response indexes, stress response indexes in serum were determined.Results: D-lactic acid, DAO, PCT, Claudin-4, TNF-α, IL-1β, Hcy, sICAM1, NE, Cor and MDA contents in serum of both groups 14 days after treatment were lower than those before treatment whereas T-AOC contents were higher than those before treatment, and bifidobacterium, lactobacillus and bacteroides contents in feces as well as T-AOC content in serum of observation group 14 d after treatment were higher than those of control group whereas enterococcus and enterobacter contents in feces as well as D-lactic acid, DAO, PCT, Claudin-4, TNF-α, IL-1β, Hcy, sICAM1, NE, Cor and MDA contents in serum were lower than those of control group. Conclusion: Bifidobacterium enteral nutrition is able to improve the intestinal flora and inhibit the systemic inflammatory stress in patients with severe stroke.