cqvip:Objective:To investigate the changes of mean platelet volume (MPV) in the course of acute pancreatitis (AP) and its value in evaluating the severity of AP.Methods: Retrospectively reviewed the clinical data of 214 patients with acute pancreatitis. According to the severity of the disease, the patients were divided into 64 patients with severe acute pancreatitis, 150 patients with non-severe acute pancreatitis. 63 healthy subjects were used as a control group. Compared the MPV levels between AP group and healthy control group. Compare the levels of MPV, CRP, LDH, Ca2+ and WBC between severe AP group and non-severe AP group. Compared the levels of MPV in acute phase and remission of acute pancreatitis. The receiver operating characteristic (ROC) curve was used to evaluate the value of MPV, CRP, LDH, Ca2+ and WBC in predicting severe acute pancreatitis.Results: Compared with the healthy control group, the MPV levels in the AP group were lower. In the acute phase and the remission period, the MPV levels in the severe AP group were lower than that in the non-severe group. The area under the ROC curve (AUC) of MPV, CRP, LDH, Ca2+ and WBC in predicting severe acute pancreatitis were 0.791, 0.655, 0.708, 0.707, 0.622.Conclusion:AP patients have lower MPV and MPV levels in remission period are higher than that in acute phase. In both acute phase and remission, MPV levels in severe AP group are lower than non-severe AP group. Compared with CRP, LDH, Ca2+ and WBC, MPV has obvious advantage in predicting severe AP.
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