Effect of Xiaoaiping combined with intravenous chemotherapy on tumor marker levels and cell viability molecule expression in patients with advanced gastric cancer

摘要

Objective:To study the effect of Xiaoaiping combined with intravenous chemotherapy on tumor marker molecule content and cell viability molecule expression in patients with advanced gastric cancer. Methods:94 patients diagnosed with advanced gastric cancer in our hospital between May 2013 and March 2016 were selected and randomly divided into Xiaoaiping group and XELOX group who received Xiaoaiping combined with XELOX therapy and XELOX therapy alone respectively. After four cycles of treatment, serum was collected to detect tumor marker levels, and gastric cancer tissue was collected to detect the expression of invasion-, proliferation-and apoptosis-related molecules. Results:After four cycles of treatment, serum carcinoembryonic antigen (CEA), carbohydrate antigen (CA199), thymidine kinase (TK)-1, Pentraxin-3 and human epididymis protein 4 (HE4) levels of Xiaoaiping group were significantly lower than those of XELOX group (P<0.05);ALDH1, CXCR4, CatE, CatS, CyclinD1, CDK4, CDC25B, Bcl-2 and Survivin expression in gastric cancer tissue of Xiaoaiping group were significantly lower than those of XELOX group (P<0.05) while Caspase-3, Caspase-9, PTEN and Beclin-1 expression were significantly higher than those of XELOX group (P<0.05). Conclusions:Xiaoaiping combined with intravenous chemotherapy for advanced gastric cancer can more effectively kill cancer cells and inhibit cancer cell proliferation and invasion.