Effect of folic acid combined with routine drugs on Hcy metabolism, inflammatory response and plaque properties in patients with H-type hypertension complicated by carotid atherosclerosis

摘要

Objective:To explore the effect of folic acid combined with routine drugs on Hcy metabolism, inflammatory response and plaque properties in patients with H-type hypertension complicated by carotid atherosclerosis.Methods: A total of 68 patients with H-type hypertension complicated by carotid atherosclerosis who received treatment in our hospital between January 2014 and September 2016 were collected and divided into control group (n=34) and observation group (n=34) according to random number table. The control group received routine therapy and the observation group received folic acid combined with routine drug therapy. The differences in Hcy metabolism, inflammatory response and plaque properties were compared between the two groups of patients before and after treatment.Results:Before treatment, differences in serum Hcy contents, pro-inflammatory and anti-inflammatory mediator contents, and ultrasound plaque property parameter levels were not statistically significant between two groups of patients. After treatment, serum Hcy content of observation group was lower than that of control group;serum pro-inflammatory factors IL-1, IL-6, IL-8 and CRP contents were lower than those of control group;serum anti-inflammatory factors IL-4, IL-10 and IL-13 contents were lower than those of control group;ultrasound plaque property parameter strain value was lower than that of control group while plaque strain rate was higher than that of control group.Conclusion:Folic acid treatment based on routine treatment can effectively accelerate the Hcy metabolism, reduce systemic inflammatory response and increase the plaque stability in patients with H-type hypertension complicated by carotid atherosclerosis.