Correlation of the expression of Eotaxin-3 and Foxm1 with the expression of p38MAPK/NF-κB and inflammatory factors in mucosa tissue of chronic sinusitis

摘要

Objective:To study the correlation of the expression of Eotaxin-3 and Foxm1 with the expression of p38MAPK/NF-κB and inflammatory factors in mucosa tissue of chronic sinusitis.Methods:57 patients with chronic sinusitis and 38 patients with nasal septum deviation who received nasal endoscopic surgery in our hospital between March 2015 and August 2016 were selected and included in sinusitis group and control group respectively. Sinus mucosa tissues were collected to test the expression of Eotaxin-3, Foxm1, p38MAPK, NF-κB and inflammatory factors, and serum samples were collected to test the levels of inflammatory factors.Results:Eotaxin-3, Foxm1, p38MAPK and NF-κB protein expression in mucosa tissue of sinusitis group were significantly higher than those of control group, and the Eotaxin-3 and Foxm1 protein expression were positively correlated with p38MAPK and NF-κB protein expression;TGF-β1, IL-1β, IL-25, IL-33 and YKL-40 levels in nasal mucosa and serum of sinusitis group were significantly higher than those of control group, and TGF-β1, IL-1β, IL-25, IL-33 and YKL-40 levels in nasal mucosa and serum were positively correlated with p38MAPK and NF-κB protein expression.Conclusion:Eotaxin-3 and Foxm1 are expressed in mucosa tissue of chronic sinusitis, and can start the expression of inflammatory factors and induce the cascade amplification of inflammatory reaction through p38MAPK/ NF-κB signaling pathway.