Effect of berberine combined with risperidone therapy on endocrine hormones and oxidative stress in patients with schizophrenia

摘要

Objective:To study the effect of berberine combined with risperidone therapy on endocrine hormones and oxidative stress in patients with schizophrenia.Methods: A total of 90 patients with schizophrenia who were treated in our hospital between May 2014 and May 2016 were collected, reviewed and then divided into the control group (n=47) who received risperidone therapy and the observation group (n=47) who received berberine combined with risperidone therapy. Serum insulin resistance index levels, thyroid hormone and prolactin contents as well as oxidative stress index contents before and after treatment were compared between two groups of patients.Results: Before treatment, differences in serum insulin resistance index levels, thyroid hormone and prolactin contents as well as oxidative stress index contents were not statistically significant between two groups of patients. After treatment, serum FINS and HOMA-IR levels in observation group were lower than those in control group;serum T3 content was higher than that in control group while PRL content was lower than that in control group;serum MDA content was lower than that in control group while SOD, GSH-Px and CAT contents were higher than those in control group.Conclusion: Berberine combined with risperidone therapy for patients with schizophrenia won''t cause severe endocrine hormone level disorder, and helps to reduce the systemic oxidative stress response.