The predictive value of serum S1P and Adropin levels for the restenosis after cerebrovascular stent implantation and their relationship with vasoactive substances and cytokines

摘要

Objective:To explore the predictive value of serum S1P and Adropin levels for the restenosis after cerebrovascular stent implantation and their relationship with vasoactive substances and cytokines.Methods:A total of 109 patients with cerebral infarction who accepted cerebrovascular stent implantation in our hospital between July 2012 and May 2016 were selected, their treatment outcome were reviewed, 35 patients with restenosis after cerebrovascular stent implantation were selected as observation group, and 74 patients without restenosis after cerebrovascular stent implantation were selected as control group. Serum S1P and Adropin levels were compared between two groups of patients before and after stent implantation, and the inner link of S1P and Adropin levels with vasoactive substance and cytokine levels in patients with restenosis after cerebrovascular stent implantation was further explored.Results: Before stent implantation, the differences in serum levels of S1P, Adropin, vasoactive substances and cytokines were not statistically significant between two groups of patients. After stent implantation, serum S1P and Adropin levels in observation group were lower than those in control group;serum vasoactive substance NO level was lower than that in control group while ET-1, TXB2 and AngⅡ levels were higher than those in control group;serum inflammatory factors TNF-α, IL-6, IL-10 and IL-13 levels were higher than those in control group. Pearson test showed that serum S1P and Adropin levels in patients with restenosis after cerebrovascular stent implantation were directly correlated with the levels of vasoactive substances and cytokines.Conclusion: Serum S1P and Adropin are lowly expressed in patients with restenosis after cerebrovascular stent implantation, and their specific expression are directly correlated with the levels of vasoactive substances and inflammatory cytokines, and can be used as the reliable indexes for early prediction of restenosis after cerebrovascular stent implantation.