Influence of laser combined with Conbercept therapy on serum cytokines and oxidation products in patients with diabetic retinopathy

摘要

Objective:To study the influence of laser combined with Conbercept therapy on serum cytokines and oxidation products in patients with diabetic retinopathy (DR).Methods: 118 cases of DR patients who were treated in our hospital between June 2014 and January 2017 were collected and retrospectively divided into the control group (n=60) who underwent laser therapy alone and the observation group (n=58) who underwent laser combined with Conbercept therapy. Serum contents of angiogenesis-related indicators, inflammatory factors, oxidative metabolites and others were compared between two groups of patients before and after treatment.Results: Before treatment, differences in serum contents of angiogenesis-related indicators, inflammatory factors and oxidative metabolites were not statistically significant between two groups of patients. After treatment, serum contents of angiogenesis-related indexes IGF-1, VEGF, EPO, TGF-β and bFGF in observation group were lower than those in control group;contents of inflammatory factors IL-1β, IL-6 and IL-8 were lower than those in control group;contents of oxidative metabolites MDA, AOPPs, LHP and ROS were lower than those in control group.Conclusion: Laser combined with Conbercept therapy can effectively inhibit ocular angiogenesis and reduce systemic inflammation and oxidative stress in patients with DR.