Effect of intermittent anaerobic exercise combined with inhalant therapy on airway remodeling and inflammatory response in children with asthma

摘要

Objective: To study the effect of intermittent anaerobic exercise combined with inhalant therapy on airway remodeling and inflammatory response in children with asthma. Methods:A total of 92 children who were diagnosed with bronchial asthma in Zigong Third People''s Hospital between June 2015 and February 2017 were selected as the research subjects and randomly divided into exercise group and control group who received intermittent anaerobic exercise combined with inhalant therapy and regular inhalant therapy respectively. Results:4 weeks and 8 weeks after intervention, serum MMP2, MMP3, MMP9, ADAM33,TGF-β1, Smad3, CTGF, PINP, PIIINP, IL-4, IL-9, IL-21, TNF-α and hs-CRP levels of both groups of patients were significantly lower than those before intervention while TIMP1 levels were significantly higher than those before intervention, and serum MMP2, MMP3, MMP9, ADAM33,TGF-β1, Smad3, CTGF, PINP, PIIINP, IL-4, IL-9, IL-21, TNF-α and hs-CRP levels of exercise group were significantly lower than those of control group while TIMP1 levels were significantly higher than those of control group. Conclusion: Intermittent anaerobic exercise combined with inhalant therapy can improve airway remodeling and inflammatory response in children with asthma.