Ultrasonic evaluation of uterine spiral artery characteristics in patients with gestational hypertension and their correlation with the placental hypoxia injury

摘要

Objective: To investigate the ultrasonic evaluation of uterine spiral artery characteristics in patients with gestational hypertension and their correlation with the placental hypoxia injury. Methods: A total of 128 puerperae with gestational hypertension who gave birth in this hospital between December 2014 and February 2017 were collected as gestational hypertension group, and 100 healthy puerperae who gave birth in this hospital during the same period were collected as normal control group. The differences in uterine spiral artery parameter levels as well as the contents of angiogenesis indexes, oxidative stress indexes and inflammatory mediators in the placental grinding fluid were compared between the two groups 1 week before delivery. Pearson test was used to evaluate the correlation between uterine spiral artery characteristics and placental hypoxia injury in patients with gestational hypertension. Results: Uterine spiral artery RI, PI and S/D levels in gestational hypertension group were higher than those in normal control group;angiogenesis indexes HIF-1α, VEGF and sFlt-1 contents in placental grinding fluid of gestational hypertension group were higher than those of normal control group;anti-oxidation indexes CTA and SOD contents were lower than those of control group whereas LHP content was higher than that of normal control group;inflammatory mediators IL-6, TNF-α, NF-κB and HSP70 contents were higher than those of normal control group. Pearson test showed that the uterine spiral artery RI, PI and S/D levels in puerperae with gestational hypertension were positively correlated with the degree of angiogenesis, oxidative stress and inflammatory response in the placenta. Conclusion: There are abnormal changes of uterine spiral artery flow parameters in puerperae with gestational hypertension, and the abnormality can objectively reflect the degree of placental hypoxia injury.