Serum platelet-activating factor level of patients with cerebral infarction from TIA and its correlation with coagulation function and inflammatory response

摘要

Objective: To study the serum platelet-activating factor (PAF) level of patients with cerebral infarction from transient ischemic attack (TIA) and its correlation with coagulation function and inflammatory response. Methods: TIA patients who were hospitalized in Neurology Department of Foshan Second People''s Hospital between September 2016 and July 2017 were selected and divided into simple TIA group and cerebral infarction group according to the progression into cerebral infarction or not within 1 week;healthy subjects who received physical examination during the same period were selected as the control group. Serum levels of PAF, coagulation function indexes and inflammation indexes were detected. Results: Serum PAF, FVIII, vWF, TNF-α, hs-CRP, MCP-1 and IL-17 contents of cerebral infarction group and simple TIA group were significantly higher than those of control group while PT, APTT and TT levels were significantly shorter than those of control group;serum PAF, FVIII, vWF, TNF-α, hs-CRP, MCP-1 and IL-17 contents of cerebral infarction group were significantly higher than those of simple TIA group while PT, APTT and TT levels were significantly shorter than those of simple TIA group;serum FVIII, vWF, TNF-α, hs-CRP, MCP-1 and IL-17 contents of TIA patients with high PAF content were significantly higher than those of TIA patients with low PAF content while PT, APTT and TT levels were significantly shorter than those of TIA patients with low PAF content. Conclusion: Excessively generated PAF can promote TIA progression to cerebral infarction by activating coagulation pathway and inflammatory response.