Effect of Danhong injection combined with irbesartan on oxidative stress and renal function damage in patients with diabetic nephropathy

摘要

Objective: To study the effect of Danhong injection combined with irbesartan on oxidative stress and renal function damage in patients with diabetic nephropathy. Methods: Patients with diabetic nephropathy who were treated in hospital of Minzu University of China between April 2013 and February 2017 were selected, and random number table was used to divide them into Danhong + ARB group and ARB group who received routine hypoglycemic + Danhong injection + irbesartan therapy and routine hypoglycemic + irbesartan therapy respectively. The serum levels of renal function biochemical indexes, platelet activation indexes and oxidative stress indexes of the two groups of patients were detected before and 6 weeks after treatment. Results: After treatment, serum BUN, Cr, β2-MG, Cys-C, PECAM-1, CD62p, PAC-1, MDA, 8-OHdG and 8-iso-PGF2a levels of both groups of patients were significantly lower than those before treatment while T-AOC, Cu-Zn-SOD, Mn-SOD and GPx-1 levels were significantly higher than those before treatment and serum BUN, Cr, β2-MG, Cys-C, PECAM-1, CD62p, PAC-1, MDA, 8-OHdG and 8-iso-PGF2a levels of Danhong + ARB group after treatment were significantly lower than those of ARB group while T-AOC, Cu-Zn-SOD, Mn-SOD and GPx-1 levels were significantly higher than those of ARB group. Conclusion: Danhong injection combined with irbesartan therapy for diabetic nephropathy can reduce renal function damage and improve oxidative stress response.