Evaluation of the general conditions and inflammatory response of antibiotics combined with fat-soluble vitamin therapy for pediatric pneumonia

摘要

Objective: To evaluate the general conditions and inflammatory response of antibiotics combined with fat-soluble vitamin therapy for pediatric pneumonia. Methods: A total of 350 children with pneumonia who were treated in our hospital between January 2014 and January 2017 were collected and divided into control group and observation group according to the random number table, 175 cases in each group. Control group received azithromycin therapy, and observation group received azithromycin combined with fat-soluble vitamin therapy. The differences in the systemic and inflammatory responses before and after treatment were compared between the two groups of patients. Results: Before treatment, differences in blood routine index levels as well as serum contents of oxidative stress indexes and inflammatory factors were not statistically significant between two groups of patients. After treatment, white blood cell count, neutrophil ratio as well as serum CRP, PCT, IL-6 and TNF-α contents of both groups were lower than those before treatment while lymphocyte ratio as well as serum IgA, IgG and IgM contents were higher than those before treatment, and white blood cell count, neutrophil ratio as well as serum CRP, PCT, IL-6 and TNF-α contents of observation group after treatment were lower than those of control group while lymphocyte ratio as well as serum IgA, IgG and IgM contents was higher than those of control group. Conclusion:Antibiotics combined with fat-soluble vitamin therapy for pediatric pneumonia can effectively optimize the patient''s general conditions and reduce the inflammatory response.