Effect of laparoscopic surgery on serum inflammatory factors,VEGF,MMP-9,oxidative stress and immune function in patients with colorectal cancer

摘要

Objective: To investigate the effects of laparoscopic surgery on serum inflammatory factors, vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), oxidative stress and immune function in patients with colorectal cancer. Methods: According to the random data table 103 cases of colorectal cancer patients were divided into the control group (n=52) and observation group (n=51), patients in the control group were treated with traditional open surgery, and observation group patients were given laparoscopic surgery, preoperative and postoperative 1 d, the levels of serum inflammatory factor, VEGF, MMP-9, oxidative stress and immune function of the two groups were compared. Results: There were no significant differences in TNF-α, IL-6, CRP, VEGF, MMP-9, MDA, SOD, CD4+, CD8+, CD4+/CD8+levels between the two groups before operation. Postoperative 1 d, the levels of TNF-α, IL-6, CRP, MDA and CD8+in the two groups were significantly higher than those in the same group preoperative, and the observation group was significantly lower than the control group, the difference was statistically significant;Two groups of VEGF, MMP-9, SOD, CD4+and CD4+/CD8+were significantly lower than those in the group before the operation, and the observation group VEGF, MMP-9 levels were significantly lower than those in the control group, SOD, CD4+, CD4+/CD8+levels of the observation group were significantly higher than the control group, the difference was statistically significant. Conclusion: Compared with open surgery, laparoscopic surgery for colorectal cancer, can effectively reduce the release of light inflammatory factors, decrease VEGF, MMP-9 levels, less influence on oxidative stress and immune function of patients, has a certain clinical value.