Effect of hyperbaric oxygen combined with drug therapy on cerebral blood flow characteristics, nerve injury and nerve cytokines in the convalescence of hypertensive cerebral hemorrhage

摘要

Objective:To study the effect of hyperbaric oxygen combined with drug therapy on cerebral blood flow characteristics, nerve injury and nerve cytokines in the convalescence of hypertensive cerebral hemorrhage.Methods:A total of 215 patients who were in convalescence of hypertension cerebral hemorrhage and treated in our hospital between January 2013 and January 2017 were collected and divided into the control group (n=109) who received conventional therapy and the observation group (n=106) who received adjuvant hyperbaric oxygen therapy, and both therapies lasted for 1 month. The differences in nerve function and neurotrophic state were compared between the two groups of patients before and after treatment.Results: Before treatment, differences in the levels of cerebral hemodynamic index levels as well as nerve injury index, amino acid neurotransmitter and neurotrophic factor contents were not statistically significant between the two groups of patients. After 1 month of treatment, Vmean and Qmean levels as well as serum GABA, Gly, BDNF, NGF and NTF contents of both groups of patients were higher than those before treatment while R and Wv levels as well as serum S100B, GEAP, NSE, Glu and Asp contents were lower than those before treatment, and Vmean and Qmean levels as well as serum GABA, Gly, BDNF, NGF and NTF contents of observation group were higher than those of control group while R and Wv levels as well as serum S100B, GEAP, NSE, Glu and Asp contents were lower than those of control group.Conclusion: Adjuvant hyperbaric oxygen therapy can effectively reduce the nerve injury and optimize the neurotrophic state of patients in the convalescence of hypertensive cerebral hemorrhage.