Correlation of serum SFRP5 and Klotho expression with oxidative stress and adipocytokine secretion in patients with diabetic nephropathy

摘要

Objective: To investigate the correlation of serum SFRP5 and Klotho expression with oxidative stress and adipocytokine secretion in patients with diabetic nephropathy. Methods: A total of 180 patients with DN were selected as DN group and 100 healthy volunteers were selected as normal control group. The differences in serum SFRP5 and Klotho expression as well as oxidative stress index and adipocytokine levels were compared between the two groups. Pearson test was used to evaluate the correlation of serum SFRP5 and Klotho expression with oxidative stress and adipocytokine secretion in DN patients. Results: Serum SFRP5 and Klotho levels of DN group were lower than those of normal control group;oxidative stress indexes MDA and LHP levels were higher than those of normal control group whereas SOD and CAT levels were lower than those of control group;adipocytokines Visfatin, Nesfatin-1 and APN levels were lower than those of normal control group whereas LEP level was higher than that of normal control group. Pearson test showed that serum SFRP5 and Klotho expression in patients with DN were directly correlated with the oxidative stress index levels and adipocytokine secretion. Conclusion: Serum SFRP5 and Klotho expression are extremely low in patients with DN, and the specific expression can objectively reflect the oxidative stress extent and the abnormal secretion of adipocytokines.