Effect of methoxamine hydrochloride on the cardiac work, myocardial damage and oxidative stress in elderly patients during general anesthesia induction

摘要

Objective: To study the effect of methoxamine hydrochloride on the cardiac work, myocardial damage and oxidative stress in elderly patients during general anesthesia induction. Methods:Elderly patients who received non-cardiac surgery under general anesthesia in Xianshuigu Hospital between April 2014 and December 2016 were selected and randomly divided into two groups, observation group received methoxamine hydrochloride combined with routine anesthesia, and control group received routine anesthesia. After the completion of anesthesia induction and operation, the cardiac work indexes, myocardial damage indexes, oxidative stress indexes and immune response indexes of the two groups were measured. Results: SVI and LVSW levels as well as serum NE, E, Cor, Ins and C-P contents of observation group after completion of anesthesia induction and operation were significantly lower than those of control group, serum CK-MB, cTnI, cTnT and Caspase-3 contents were not significantly different from those of control group, and peripheral blood CD3+CD4+, CD3+CD8+, CD1α+, CD80+ and CD86+ expression intensity were significantly higher than those of control group. Conclusion: Methoxamine hydrochloride for general anesthesia induction of elderly patients can reduce the cardiac work and inhibit the oxidative stress response.