Effect of Aidi injection-assisted intravenous chemotherapy on serum tumor markers and peripheral blood immune molecules in patients with colon cancer

摘要

Objective:To discuss the effect of Aidi injection-assisted intravenous chemotherapy on serum tumor markers and peripheral blood immune molecules in patients with colon cancer. Methods: 92 patients with colon cancer who were hospitalized in Deyang People''s Hospital in Sichuan Province between October 2013 and October 2016 were collected and divided into the control group (n=50) who received intravenous chemotherapy alone and the observation group (n=42) who received Aidi injection-assisted intravenous chemotherapy after the therapies were reviewed. The differences in serum tumor markers and peripheral blood immune molecule contents before and after treatment were compared between two groups of patients.Results:Before treatment, differences in serum tumor marker levels and peripheral blood immune molecule levels were not statistically significant between two groups of patients. After treatment, serum tumor markers CEA, CA199, CA50, PTN and CCSA-2 levels of observation group were lower than those of control group, peripheral blood Th1/Th2 cytokines IL-2 and IFN-γ levels were higher than those of control group while IL-4 and IL-10 levels were lower than those of control group, and peripheral blood Th17 cytokines IL-17A and IL-22 levels were lower than those of control group.Conclusion: Aidi injection-assisted intravenous chemotherapy can effectively reduce the serum tumor marker contents and optimize the immune molecule levels in patients with colon cancer.