Change and significance of serum inflammatory factors, vWf, VEGF and adhesion molecules in patients with diabetic nephropathy

摘要

Objective: To investigate the change of serum inflammatory factors, von Willebrand factor (vWf), vascular endothelial growth factor (VEGF) and adhesion molecule levels in diabetic nephropathy patients (DN), and their significance in the detection of diabetic nephropathy. Methods: According to urinary albumin excretion rate (UAER), a total of 158 cases of diabetic patients were divided into T2DM group (Simple diabetes group, n=52) and DN group (diabetic nephropathy group, n=106), group DN were divided into microalbuminuria group (n=54) and macroalbuminuria group (n=52);At the same time, 50 healthy subjects were selected as control group, the levels of serum inflammatory factors (hs-CRP, IL-6 and TNF-α), vWf, VEGF and adhesion molecules (sVCAM-1, sICAM-1 and E- selectin) in these four groups were compared. Results: The levels of hs-CRP, IL-6, vWf, VEGF, TNF-α, sVCAM-1, sICAM-1 and E- selectin in the T2DM group and DN group were significantly higher than those in the control group, and DN group was significantly higher than that in T2DM group, the difference was statistically significant;In the DN group, compared with microalbuminuria group, the levels of hs-CRP, IL-6, vWf, VEGF, TNF-α, sVCAM-1, sICAM-1 and E- selectin in the macroalbuminuria group were significantly increased, the difference was statistically significant. Conclusion: Serum inflammatory factors, vWf, VEGF and adhesion molecules may play important roles in the course of the genesis and development of DN. It has great value to the assessment of this disease.