Correlation of serum Tau and 8-iso-PGF2α levels with nerve injury and oxidative stress in patients with traumatic brain injury

摘要

Objective: To study the correlation of serum Tau and 8-iso-PGF2α levels with nerve injury and oxidative stress in patients with traumatic brain injury. Methods: A total of 56 patients who were diagnosed with traumatic brain injury in Pidu District People''s Hospital between May 2014 and February 2017 were selected as the TBI group, and 45 volunteers who received physical examination in the hospital during the same period were selected as control group. Serum samples were collected to determine the contents of Tau, 8-iso-PGF2α, nerve cell apoptosis molecules and anti-oxidation molecules. Results: Serum Tau, 8-iso-PGF2α, Bax, Caspase-3 and Caspase-9 levels in TBI group were significantly higher than those in control group while Bcl-2, GSH, VitE, GSH-Px, SOD and HO-1 levels were significantly lower than those in control group;serum Bax, Caspase-3 and Caspase-9 levels in TBI patients with higher Tau level were significantly higher than those in TBI patients with lower Tau level while Bcl-2 level was significantly lower than that in TBI patients with lower Tau level;serum GSH, VitE, GSH-Px, SOD and HO-1 levels in TBI patients with higher 8-iso-PGF2α level were significantly lower than those in TBI patients with lower 8-iso-PGF2α level. Conclusion:Abnormal elevation of Tau and 8-iso-PGF2α levels in serum of patients with traumatic brain injury is related to the excessive apoptosis of nerve cells and the excessive activation of oxidative stress.