胚胎神经干细胞移植治疗脑出血后遗症疗效观察

摘要

Objective To evaluate the clinical effects of embryonic stem cell( ESC )treating cerebral hemorrhage sequelae. Methods 5 patients with an average age of 55, including 2 with post-surgery basal ganglia hemorrhage,2 with internal capsule hemorrhage, and 1 with thalamus hemorrhage were studied. The operation was conducted via lumbar puncture in the operation room. Stem cell suspension( 3 mL )with the quantity of 108 ,0.9％ sodium chloride injection( 1 mL )and desamethasone injection( 5 mg )are injected into the patients during the operation. The operation is done on a weekly basis, and the patients receive 4 injections altogether. The result is scored by unified standard on dysneuria extent. Results 2 patients developed a low fever( around 37.6 ～ 38.0℃ )in 1 to 36 hours after ESC transplantation. 3 patients felt headache and dizzy. 2 patients developed lumbago and skelalgia. Conclusion ESC transplantation is effective in treating cerebral hemorrhage sequelae. The patients' life quality improves significantly after ESC treatment.%目的 观察胚胎神经干细胞移植治疗脑出血后遗症的临床疗效.方法 5例患者,平均55岁,其中基底节出血术后2例,内囊出血2例,丘脑出血1例.选择胚胎神经干细胞治疗,在手术室腰椎穿刺植入3 mL内含108级的干细胞混悬液,同时注入0.9%氯化钠注射液1 mL;地塞米松注射液5 mg,每周1次,共4次.采用统一神经功能缺损评定评分.结果 胚胎神经干细胞移植后1 ～36 h 2例出现发热,体温为37.6 ～38.0°C,3例头痛、头晕,2例出现腰痛和腿痛.结论 胚胎神经干细胞移植对改善脑出血后遗症有效,显著提高生存质量.