多巴胺与去甲肾上腺素在感染性休克中的应用进展

摘要

Septic shock is a complex clinical syndrome with a high mortality, as one the of most frequent causes of intensive care unit deaths that seriously threaten human health. Dopamine and norepinephrine can be used as the first-line hypertensive agents due to their remarkable effects on kidney and other organs, whereas dopamine has a more significant tachycardiac effect than norepinephrine. In the treatment of septic shock, early diagnosis and identification of mortality-associated risk factors are required, including more evidence-based medicine involvement. Appropriate and potent management in attempt to maximize the rescue rate of septic shock is critical for the minimization of mortality.%感染性休克是一种复杂、高病死率的临床综合征,是重症监护病房最常见的死亡原因之一,严重威胁着人类的健康.多巴胺和去甲肾上腺素对肾脏及其他内脏均产生重要的影响,可作为一线升压药物,但多巴胺较去甲肾上腺素加快心率的作用更明显.在治疗感染性休克过程中,应早期诊断及识别一些死亡危险因素,也需要更多的循证医学证据,以期及时给予有力的干预措施,进一步提高感染性休克的救治成功率,这是降低病死率的关键.