目的：对比分析埃索美拉唑和奥美拉唑为主的三联疗法对胃溃疡的治疗效果,为临床治疗提供参考。方法将2011年8月至2013年6月房县人民医院收治的190例胃溃疡患者按照随机数字表法分为埃索美拉唑组95例和奥美拉唑组95例,比较两组治疗效果。结果埃索美拉唑组治疗总有效率为97.9%,显著高于奥美拉唑组的83.2%,P<0.05；埃索美拉唑组Hp根治率为91.6%,显著优于奥美拉唑组的74.7%,P<0.05；两组治疗前治疗前临床症状比较差异无统计学意义,P>0.05；治疗8周后,两组临床症状改善总积分均改善,P<0.05,埃索美拉唑组临床症状改善总积分均低于奥美拉唑组,P<0.05。结论以埃索美拉唑肠溶片为主的三联疗法治疗胃溃疡效果好,具有较好的临床应用前景。%Objective To compare the efficacy comparision of two kinds triple therapy methods for gas-tric ulcer patients. Methods 190 cases of gastric ulcer patients from August 2011 to June 2013 in Fang County People′s Hospital were randomly divided into Esomeprazole group and the Omeprazole group,and the treatment effects were compared. Results The total effective rate of the Esomeprazole group (97. 9%) was significantly higher than that of the control group(83. 2%) (P<0. 05). The Hp radical situation rate of the the Esomeprazole group (91. 6%) was significantly higher than that of the Omeprazole group(74. 7%) (P<0. 05). There was no difference between of total score of the clinical symptoms in the two groups before the treatment(P>0. 05). After 8 weeks′treatment,the total score of the clinical symptoms of the two groups were both improved (P<0.05) and the observed group were better than those of the control group(P<0.05). Conclusion The triple therapy based on esomeprazole enteric-coated tablets has better treatment for gastric ulcer patients,which could significantly improve the cure efficiency, increase the Hp cure rate and improved the clinical symptoms. Which showed better clinical application prospects.
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