LncRNA与miRNA的交互作用及调控机制对肿瘤发生与发展过程的影响

摘要

长链非编码 RNA(LncRNA)被作为人类基因组中重要的调控分子之一,通过多种方式发挥其生物学调控功能. 研究表明, LncRNA 也可作为一种竞争性的内源性 RNA 与非编码微 RNA (miRNA)交互作用,共同参与靶向基因的调控,对肿瘤发生与发展过程产生重要影响. 同时,miRNA通过大量蛋白质编码基因靶向调控LncRNA的表达,miRNA和LncRNA在调节细胞过程均有重要作用. 该文在分别介绍miRNA与LncRNA功能的基础上,总结 miRNA与 LncRNA 交互作用及调控机制对肿瘤发生与发展过程的影响.%As one of the important regulatory molecules in human genome long noncoding RNA ( Ln-cRNA) can develop its biological regulatory function in various aspects.Studies of recent years have shown that:LncRNA can interact with miRNA as a kind of competitive and endogenous RNA ,and they can partici-pate in the targeted gene regulation together ,which has important influence on the formation and progression of tumor.Meanwhile,miRNA can also make targeted regulation of the expression of LncRNA with a large a-mount of protein encoding genes,both miRNA and LncRNAs play important roles in the regulation of cellular processes.Besides the functions of miRNA and LncRNA,here is to make a review of the influence of interac-tion between miRNA and LncRNA as well as their regulatory mechanisms on the formation and progression of tumor.