甲胎蛋白阴性原发性肝癌诊断进展

摘要

原发性肝癌是我国较常见的恶性肿瘤之一,目前其临床诊断于血清学标志物和相关影像学技术. 甲胎蛋白作为敏感性及特异性较高的肝细胞癌肿瘤标志物,广泛应用于临床的筛检、早期诊断及治疗过程. 但是临床中约有1/3 的肝癌患者血清甲胎蛋白水平正常,对于这部分患者,分析甲胎蛋白阴性肝癌病理特征,相关新的特异性标志物的探索,影像学技术的合理应用,是需要进一步研究的内容.%Primary liver cancer is one of the more common malignancies in China ,and the clinical diag-nosis currently depends on serological markers and related imaging techniques .Alpha-fetoprotein( AFP) as a hepatic celluler cancer tumor marker of high sensitivity and specificity ,is widely used in the clinical screen-ing,early diagnosis and treatment process.However,about one-third of total cases of liver cancer have normal level of AFP,for these patients,analyzing of pathological features,and exploring new specific markers,rational application of imaging techniques are needed .