低密度脂蛋白亚组分与冠心病的研究进展

摘要

Increasing low density lipoprotein (LDL) cholesterol levels are one of the major risk factors for coronary heart disease.Because the treatment of traditional lipid risk factors can only reduce the coronary heart disease in some patients,there are more and more research on the LDL subgroup.However,LDL has obvious heterogeneity in the density, size and volume of particles,while small dense-LDL is the main risk factor leading to atherosclerosis.It is closely associated with the occurrence and development of coronary heart disease.Therefore, small dense-LDL can be used as one of the new risk factors for coronary heart disease.In the future,it is suggested to develop a unified method of lipoprotein subgroup typing and detection,and study the mechanism of the related drugs to reduce LDL.%低密度脂蛋白(LDL)胆固醇水平升高是导致冠心病的主要危险因素之一.由于针对传统脂质危险因素进行的治疗只能减少部分患者冠心病事件发生,所以对LDL亚组分的研究越来越多.然而,LDL在颗粒的密度、大小、体积上具有明显的异质性,其中小而密LDL是导致动脉粥样硬化的主要危险因素,其与冠心病的发生、发展有密切联系.因此,可将小而密LDL作为导致冠心病的新的危险因素之一.未来,应制订统一的脂蛋白亚组分型及检测方法,并进一步研究相关药物降低LDL亚组分的机制.