Ghrelin is a peptide released primarily from the stomach .Ghrelin receptors are present throughout the heart and vasculature and have been associated with molecular pathways .Ghrelin shows powerful cardioprotective effects including enhancing endothelial and vascular function ,preventing atherosclerosis ,decreasing blood pressure and inhibiting sympathetic activity.Exogenous administration of Ghrelin reduces the incidence of fatal arrhythmias ,and attenuates apoptosis and ven-tricular remodeling ,leads to improvements in heart failure ,and improves cachexia status in patients with end-stage conges-tive heart failure .Nonetheless ,since Ghrelin′s discovery is a relatively recent event ,a substantial amount of research is still needed to understand its clinical significance in cardiovascular diseases .%饥饿素(Ghrelin)是一种主要由胃分泌的肽类激素.Ghrelin受体存在于心脏和血管中,并通过分子通路与之联系.Ghrelin具有强大的心脏保护作用,包括增强内皮和血管功能,预防动脉粥样硬化,降低血压、抑制交感神经活动等.应用外源性Ghrelin可降低致命性心律失常发生率,减轻心肌细胞凋亡及心室重构,改善心力衰竭,并改善终末期充血性心力衰竭患者的恶病质状态.由于发现Ghrelin的时间相对较短,仍需要大量的研究来了解其在心血管疾病中的临床意义.
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