蛛网膜下腔出血预后相关生物标志物研究进展

摘要

蛛网膜下腔出血(SAH)是神经外科的常见急症,病情变化快,进展迅速,致残、致死率极高.目前,通过临床评分、影像学表现等可对SAH患者的预后进行评估,但准确度有限.随着学者对SAH发生、发展机制的深入研究,发现了一系列生物标志物与SAH的预后有一定的相关性.这些标志物参与了由SAH所引起的代谢反应的一部分,主要包括脑损伤标志物、炎症标志物、血管病理学标志物等,但目前尚未证明它们是预测SAH预后的有用工具.希望通过研究与SAH预后相关的生标志物,从而对SAH的进展进行干预,为临床治疗提供新的思路.%Subarachnoid hemorrhage ( SAH) is a common emergency in neurosurgery .The disease changes and progres-ses rapidly,and the disability and mortality of patients are extremely high .At present,the prognosis of SAH can be evaluated by clinical scores ,imaging findings etc ,but the accuracy is quite limited .Along with the extensive study of the occurrence and development mechanisms of SAH ,it′s discovered that a series of biomarkers have certain relevance with the prognosis . These biomarkers are involved in some of the metabolic reactions caused by SAH ,mainly including inflammation biomark-ers,indicators of brain damage ,and markers of vascular pathology etc .However,none of these biomarkers has been demon-strated as a useful tool for predicting outcome of SAH .It′s hoped to prevent the progression of SAH and get new ideas for clinical treatment strategy by studying the biomarkers related to the prognosis of SAH .