血细胞分析仪检测网织血小板对血小板减少性疾病的临床意义

摘要

Objective:To evaluate the significance of reticulated platelets in peripheral blood on the diagnosis of thrombocytopenic disordors. Methods:RP percentage was determined by Sysmex XE-5000 in the peripheral blood from 40 ITP patients,35 aplastic anemia(AA)patients and 60 healthy people,and the absolute value of RP was calculated.Results:RP percentage(23.61±7.26%)in the ITP group significantly higher(P<0.01)than that in control group(7.62±2.01 % ),and RP absolute value(8.36±4.01 ×109/L)was lower,compared with control group(21.35±7.78×109/L)(P<0.05).After the treatment effect was obviously improved,RP percentage was markedly reduced(8.58±1.97%),significantly different from that before treatment (P<0.01).Both the percentage(4.12±1.81) % (P<0.05)and absolute value(2.63±1.22) ×109/L(P<0.01) in the AA group was lower than control group.Conclusions:Reticulated platelet count may contribute to the aetiology determination of the thrombocytopenia and it has certain clinical significance in the investigation of treatment effect.%目的：研究血细胞分析仪检测网织血小板(RP)对血小板减少性疾病诊断和治疗的临床意义。方法：用XE-5000血细胞分析仪检测40例ITP,35例AA及60例正常人外周血的网织血小板百分比(RP%)，并计算RP绝对值。结果：ITP组RP百分比为(23.61±7.26)%，明显高于对照组(7.62±2.01)％)(P<0．01)，其RP绝对值为(8.36±4.01)×109/L，则低于对照组(21.35±7.78)×109/L（P<0.05）,ITP患者经过治疗好转后RP百分比明显降低(8.58±1.97)％，与治疗前比有统计学意义(P<0．01)；AA组RP百分比((4.12±1.81)％)（P<0.05）和RP绝对值(2.63±1.22)×109/L (P<0．01)都低于对照组。结论：血细胞分析仪检测RP简便易行，对于血小板减少性疾病的诊断，鉴别诊断以及疗效观察有重要价值。