N末端B型钠尿肽原在妇产科心源性与非心源性呼吸困难的临床鉴别价值

摘要

目的：通过检测妇产科呼吸困难患者血清N末端B型钠尿肽原(NT-proBNP)水平，探讨NT-proBNP在心源性和非心源性呼吸困难的临床鉴别价值。方法：在对妇产科病房69例急性呼吸困难患者临床干预前抽取静脉血，检测血清NT-proBNP，采用电化学发光免疫分析（ECLIA）法。结果：心源性呼吸困难组患者血清NT-proBNP水平显著高于非心源性呼吸困难组患者（P＜0.01），其阳性率也显著高于后者（P＜0.01）。以血清NT-proBNP＞100pg/ml为标准诊断心源性呼吸困难时，敏感度、特异度、阳性预测值及阴性预测值分别为：100%、92.9%、95.4%和100%；据血清NT-proBNP＞130pg/ml为标准诊断心源性呼吸困难时，敏感度、特异度、阳性预测值及阴性预测值均为100%。结论：妇产科心源性呼吸困难患者血清NT-proBNP水平显著高于非心源性呼吸困难患者，血清NT-proBNP可作为鉴别心源性与非心源性呼吸困难的一项观察指标，具有敏感性和特异性高的特点。%Objective:Through detection of obstetrics and gynecology difficulty breathing patients, the serum levels of NT-proBNP explore source sex heart and non clinical differential value of cardiac dyspnea. Methods:In maternity wards in 69 patients with acute dyspnea extraction of venous blood before clinical intervention, to detect serum NT-proBNP, by ECLIA method. Results:Cardiac dyspnea group had a significantly higher serum level of NT-proBNP than patients with non cardiac patients with dyspnea group(P<0.01), the positive rate was also significantly higher than the latter(P<0.01).According to the serum NT-proBNP>100pg/ml of standard in the diagnosis of cardiac dyspnea, sensitivity and positive predictive value and negative predictive value and specific degrees, respectively, 100% and 92.9% and 95.4% and 100%.According to the serum NT-proBNP>130pg/ml for the standard in the diagnosis of cardiac dyspnea, sensitivity and specific degrees and positive predictive value and negative predictive value of 100%. Conclusions:Obstetrics and gynecology patients with cardiac dyspnea is significantly higher than the level of serum NT-proBNP in patients with cardiac dyspnea, NT-proBNP serum can be used as identification of cardiac and non cardiac dyspnea an observational indexes, has the characteristics of high sensitivity and specificity.