VCAM-1和AOPP与妊娠期糖尿病患者母婴结局的关系研究

摘要

Objective To study the correlation between VCAM-1/AOPP levels and maternal and neonatal outcomes of GDM patients.Methods The research involved 125 GDM patients ("the GDM group") and 108 healthy pregnant women ("the control group").GDM-related indicators and VCAM-1 and AOPP levels in maternal blood and cord blood were tested to analyze the correlation between VCAM-1/AOPP and maternal and neonatal outcomes.Results Indictors including FBG,glycated hemoglobin,LDL and content of apolipoprotein B in the GDM group were significandy higher than those in the control group while HDL and apolipoprotein A were significantly lower than those in the control group (P ＜ 0.05).VACM-1 and AOPP levels in maternal blood and cord blood in the GDM group were significantly higher than those in the control group (P ＜ 0.05);the success rate of pregnancy and the loss rate of pregnancy in the GDM group were 95.20％ and 4.80％ separately;the VCAM-1 and AOPP levels in maternal blood of the women who were successfully pregnant were significantly lower than those of the women having failed in pregnancies(P ＜ 0.05);in the GDM group,the VCAM-1 and AOPP levels in maternal blood of those with obstetric complications (61.60％) were significantly higher than those without obstetric complications (P ＜ 0.05);in the 125 newborns in the GDM group,there were macrosomia (32％),premature (13.6％),infants of low birth weight (6.4％),neonatal hypoglycemia infants (4.8％),neonatal asphyxia (3.2％) and stillbirth (1.6％),of which the VCAM-1 and AOPP levels in cord blood were significantly higher than those of normal newborns (P ＜ 0.05).Conclusion VCAM-1 and AOPP levels in serum and cord blood of GDM pregnant women are significantly higher than those of normal pregnant women.The rise of VCAM-1 and AOPP levels is closely related to adverse maternal and neonatal outcomes.%目的 研究血管细胞黏附分子-1 (VCAM-1)和晚期氧化蛋白产物(AOPP)与妊娠期糖尿病(GDM)患者母婴结局的关系.方法 纳入125例GDM患者(GDM组)和108例健康孕妇(对照组),检测GDM相关指标、母血和脐带血VCAM-1及AOPP含量,分析VCAM-1和AOPP与母婴结局的关系.结果 GDM组空腹血糖、糖化血红蛋白、低密度脂蛋白、载脂蛋白B含量显著高于对照组,高密度脂蛋白、载脂蛋白A显著低于对照组(P＜ 0.05);GDM组母血和脐带血的VACM-1和AOPP含量均显著高于对照组(P＜ 0.05);GDM组妊娠成功率95.20％,妊娠丢失率4.80％,妊娠成功者母血VCAM-1和AOPP水平显著低于丢失者(P＜ 0.05);GDM组中,发生产科并发症者(61.60％)的母血VCAM-1和AOPP水平均显著高于无并发症者(P＜0.05);GDM组125例新生儿中,巨大儿32％,早产儿13.6％,低体重儿6.4％,新生儿低血糖4.8％,新生儿窒息3.2％,死胎1.6％,其脐带血VCAM-1和AOPP水平均显著高于足月正常新生儿(P＜0.05).结论 GDM孕妇血清和脐带血VCAM-1和AOPP水平显著高于正常孕妇,其水平升高与母婴不良结局密切相关.