吸入伊洛前列素对初入海拔5200m青年肺通气功能的影响

摘要

目的:观察雾化吸入伊洛前列素溶液对初人海拔5200m地区青年肺功能的影响,为促进高原习服提供新的措施,预防急性高原病.方法:16名受试者自海拔1400m历时5d进入5200 m,进入后当天检测受试者的肺通气功能(FvC、FEV1、FEV1％、MMEF、PEF和MVV),检测后采用雾化吸入伊洛前列素溶液,每次5μg,每天4次,连续5d.于吸入伊洛前列素溶液第5天再次检测受试者的肺通气功能.结果:雾化吸入伊洛前列素后,FVC (4.75±0.87 Lvs3.58±0.66 L),FEV1(4.16±0.73 L vs 3.38±0.45 L),MVV( 155.19±18.85 L vs132.12±16.27 L),均非常显著改善(P均＜0.01)；FEV1％(99.25±8.12 L vs92.79±5.48 L),MMEF(7.18±1.96 L/s vs5.69±1.37 L/s),PEF(9.46±2.25 L/s vs7.53±1.69 L/s),均显著改善(P均＜0.05).结论:在高海拔地区雾化吸入伊洛前列素溶液能提高移居者的肺通气功能.有利于高原习服和预防急性高原病.%Objective:To explore the effect of inhaling iloprost on pulmonary function of transients reached 5 200 m altitude. Methods: Sixteen subjects reached chronometer spot (5 200 m) from 1 400 m altitude. Lung function was tested ,including FVC, FEV1, FEV1%, MMEF, PEF and MVV. They inhaled iloprost four times daily for 5 days, the pulmonary function was tested at the fifth day . Results: Lung function were increased significantly(P<0.01,P<0.05)after inhaling iloprost: FVC(4.75 ±0. 87 Lvs 3.58 ±0.66 L) , FEV1(4.16± 0.73 Lvs 3.38 ±0.45 L), MVV( 155.19 ± 18. 85 L vs 132.12 ± 16.27 L); FEV1% (99.25 ±8.12 L vs 92.79 ± 5.48 L) ,MMEF(7. 18 ± 1. 96 L/s vs 5. 69 ± 1. 37 L/s), PEF(9. 46 ± 2. 25 I/s vs 7. 53 ± 1. 69 L/s). Conclusion: Iloprost can improve lung function of transients and accelerate adaptation at high altitude.