Objective: To explore clinical significance of the physiological changes of complete blood parameters and blood co-agulation four indicators for pregnant women before labor, and provide an experimental diagnostic data for preventing bleeding in the process of childbirth and after parturition. Methods: Using the Japanese Sysmex XE 2100 blood cell analyzer and the ACL TOP 700 full automatic blood coagulation instrument, 350 cases of pregnant women before labor set to the team and 120 cases of healthy not pregnant coomen of child-bearing age women set to the control group were detected with whole blood leukocyte, red blood cell and platelet parameters and blood coagulation four indicators, and the two sets of data were statistically analyzed. Results: The total white blood cells, neutrophilic granulocyte percentage, the red blood cell volume distribution width, blood platelet count, average platelet volume and platelet volume distribution width, ratio of large platelet and fibrinogen in blood coagulation four indicators of the pregnant women before labor in study group were higher than those of control group, and the differences between the two groups were statistically significant (P<0. 05). The lymphocyte percentage, intermediate cell percentage, red blood cell count, hemoglobin concentration, hematocrit, average hemoglobin content in red blood cells, red blood cell hemoglobin concentration, prothrombin time, international normalized ratio, activated partial thromboplastin of the pregnant women before labor in study group were lower than those of control group, and the differences were statistically significant (P<0. 05). Conclusions: The pregnant women before labor have a transient and physiological anemia, and blood coagulation function indicators show that blood is in high coagulation state, which can easily cause diffuse intravascular coagulation. Therefore, in the process of delivery and after delivery, they should be closely observed the maternal clinical symptoms and blood coagulation function index changes.%目的：：探讨孕妇临产前全血细胞参数、凝血4项指标生理性变化的临床意义，为预防分娩过程中及分娩后发生大出血提供实验诊断数据。方法：采用日本 Sysmex XE-2100血细胞分析仪、美国 ACL TOP 全自动血凝仪，对350例临产孕妇(设为研究组)和120例健康育龄未孕妇女(设为对照组)进行血常规及凝血4项指标检测，对两组研究对象的结果数据进行统计学分析。结果：研究组孕妇临产前白细胞总数、中性粒细胞百分比、红细胞体积分布宽度、血小板计数、血小板平均体积、血小板分布宽度、大血小板比率及凝血4项中纤维蛋白原等指标均高于对照组，两组差异有统计学意义(P<0.05)；而研究组孕妇临产前淋巴细胞百分比、中间细胞百分比、红细胞计数、全血血红蛋白浓度、红细胞压积、红细胞平均血红蛋白量、红细胞平均血红蛋白浓度、凝血酶原时间、国际标准化比值、活化部分凝血活酶时间低于对照组，差异有统计学意义(P<0.05)。结论：孕妇临产前存在一过性生理性贫血，凝血功能指标显示血液处于高凝状态，易造成弥散性血管内凝血，分娩过程中及分娩后应密切观察孕产妇临床症状及凝血功能指标变化。
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